Evidence
Nutrients. 2023 May 16;15(10):2335. doi: 10.3390/nu15102335.
ABSTRACT
Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease and represents an increasing public health issue given the limited treatment options and its association with several other metabolic and inflammatory disorders. The epidemic, still growing prevalence of NAFLD worldwide cannot be merely explained by changes in diet and lifestyle that occurred in the last few decades, nor from their association with genetic and epigenetic risk factors. It is conceivable that environmental pollutants, which act as endocrine and metabolic disruptors, may contribute to the spreading of this pathology due to their ability to enter the food chain and be ingested through contaminated food and water. Given the strict interplay between nutrients and the regulation of hepatic metabolism and reproductive functions in females, pollutant-induced metabolic dysfunctions may be of particular relevance for the female liver, dampening sex differences in NAFLD prevalence. Dietary intake of environmental pollutants can be particularly detrimental during gestation, when endocrine-disrupting chemicals may interfere with the programming of liver metabolism, accounting for the developmental origin of NAFLD in offspring. This review summarizes cause-effect evidence between environmental pollutants and increased incidence of NAFLD and emphasizes the need for further studies in this field.
PMID:37242221 | DOI:10.3390/nu15102335
Add to Google Keep
Estimated reading time: 4 minute(s)
Latest: Psychiatryai.com #RAISR4D
Real-Time Evidence Search [Psychiatry]
AI Research [Andisearch.com]
Sex, Nutrition, and NAFLD: Relevance of Environmental Pollution
🌐 90 Days
VR Related Evidence Matrix
- Enhanced non-alcoholic fatty liver detection: Computed tomography scan image analysis and noise reduction with morphological dilation
- Muscle strength and non-alcoholic fatty liver disease/metabolic-associated fatty liver disease
- Exploring the role of genetic variations in NAFLD: implications for disease pathogenesis and precision medicine approaches
- NAFLD Fibrosis Progression and Type 2 Diabetes: The Hepatic-Metabolic Interplay
- Integrated traditional Chinese and Western medicine in the prevention and treatment of non-alcoholic fatty liver disease: future directions and strategies
- MASLD: a systemic metabolic disorder with cardiovascular and malignant complications
- Iron metabolism and ferroptosis in Non-alcoholic fatty liver disease: what is our next step?
- Berberine prevents NAFLD and HCC by modulating metabolic disorders
- Occult liver disease: a multinational perspective
- Plastic compounds and liver diseases: Whether bisphenol A is the only culprit
- The therapeutic mechanisms and beneficial effects of ursodeoxycholic acid in the treatment of nonalcoholic fatty liver disease: a systematic review
- Lian-Mei-Yin formula alleviates diet-induced hepatic steatosis by suppressing Yap1/FOXM1 pathway-dependent lipid synthesis
- Advances in management of metabolic dysfunction-associated steatotic liver disease: from mechanisms to therapeutics
- Association between dietary vitamin A intake from different sources and non-alcoholic fatty liver disease among adults
- Investigating the Role of Non-Coding RNA in Non-Alcoholic Fatty Liver Disease
- Beneficial Effects of Dietary Flaxseed on Non-Alcoholic Fatty Liver Disease
- MAFLD as part of systemic metabolic dysregulation
- MAFLD as part of systemic metabolic dysregulation
- Non-alcoholic fatty liver disease promotes liver metastasis of colorectal cancer via fatty acid synthase dependent EGFR palmitoylation
- Various types of fasting diet and possible benefits in nonalcoholic fatty liver: Mechanism of actions and literature update
- Association of metabolic-dysfunction associated steatotic liver disease with polycystic ovary syndrome
- The association of Neuromedin U levels and non-alcoholic fatty liver disease: A comparative analysis
- The Global Epidemic of Metabolic Fatty Liver Disease
- Ultrasonographic findings of metabolic dysfunction-associated fatty liver disease: A comparative study with non-alcoholic fatty liver disease and clinical characteristics
- Gender-Specific Bile Acid Profiles in Non-Alcoholic Fatty Liver Disease
- Update in lean metabolic dysfunction-associated steatotic liver disease
- Update in lean metabolic dysfunction-associated steatotic liver disease
- Chronic exposure to 3,6-dichlorocarbazole exacerbates non-alcoholic fatty liver disease in zebrafish by disrupting lipid metabolism and inducing special lipid biomarker accumulation
- Comparison of all-cause mortality associated with non-alcoholic fatty liver disease and metabolic dysfunction-associated fatty liver disease
- Dairy products intake and prevalence, incidence, and recovery of non-alcoholic fatty liver disease in Chinese population
- Exposure to per- and polyfluoroalkyl substance and metabolic syndrome: A nationally representative cross-sectional study from NHANES, 2003-2018
- Comparison of NAFLD, MAFLD and MASLD characteristics and mortality outcomes in United States adults
- Natural compounds proposed for the management of non-alcoholic fatty liver disease
- Role of the angiopoietin-like protein family in the progression of NAFLD
- Interactions between the metabolic syndrome and alcohol consumption increases the risk of liver disease
- Liver Biopsy Handling of Metabolic-Associated Fatty Liver Disease (MAFLD): the Children's Hospital of Eastern Ontario grossing protocol
- Association of non-alcoholic fatty liver disease with cardiovascular disease and all cause death in patients with type 2 diabetes mellitus: nationwide population based study
- EXPRESS: Association of Statins with Onset and Progression of Non-Alcoholic Fatty Liver Disease in Patients with Diabetes
- EXPRESS: Association of Statins with Onset and Progression of Non-Alcoholic Fatty Liver Disease in Patients with Diabetes
- Anthocyanin: A Potential Phytochemical Candidate for the Amelioration of Non-Alcoholic Fatty Liver Disease
- TET3 boosts hepatocyte autophagy and impairs non-alcoholic fatty liver disease by increasing ENPP1 promoter hypomethylation
- Prevalences of Hypertension, Type 2 Diabetes Mellitus, and Cardiovascular Disease in a Cohort of Puerto Ricans with Non-alcoholic Fatty Liver Disease
- Vitamin K2 protects mice against non-alcoholic fatty liver disease induced by high-fat diet
- Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice
- What are the common downstream molecular events between alcoholic and nonalcoholic fatty liver?
- What are the common downstream molecular events between alcoholic and nonalcoholic fatty liver?
- Chronic exposure to ambient air pollution and the risk of non-alcoholic fatty liver disease: A cross-sectional study in Taiwan and Hong Kong
- Bacteroides fragilis aggravates high-fat diet-induced non-alcoholic fatty liver disease by regulating lipid metabolism and remodeling gut microbiota
- Costunolide attenuates high-fat diet-induced inflammation and oxidative stress in non-alcoholic fatty liver disease
- Metabolic-associated fatty liver disease: a selective review of pathogenesis, diagnostic approaches, and therapeutic strategies
- Metabolic Derangement in Non-Alcoholic Fatty Liver Disease: Opportunities for Early Diagnostic and Prognostic Markers
- Impact of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) on the expression and function of hepatobiliary transporters: A comprehensive mechanistic review
- Metabolic disease and the liver: A review
- Autophagy and the unfolded protein response shape the non-alcoholic fatty liver landscape: decoding the labyrinth
- Unique Genetic Features of Lean NAFLD: A Review of Mechanisms and Clinical Implications
- Clinical profiles and mortality rates are similar for metabolic dysfunction-associated steatotic liver disease and non-alcoholic fatty liver disease
- Macrophage-specific FGFR1 deletion alleviates high-fat-diet-induced liver inflammation by inhibiting the MAPKs/TNF pathways
- Increased Risk of Colorectal Adenomas with Metabolic-Associated Fatty Liver Disease Components
- Metabolic Disorders in Liver Transplant Recipients: The State of the Art
- Association of sex-specific body mass index and waist circumference trajectories with non-alcoholic fatty liver disease incidence based on growth mixture modeling
- Association between nonalcoholic fatty liver disease and incidence of inflammatory bowel disease: a nationwide population‑based cohort study
- THE GLOBAL EPIDEMIOLOGY OF NON-ALCOHOLIC FATTY LIVER DISEASE AND NON-ALCOHOLIC STEATOHEPATITIS AMONG PATIENTS WITH TYPE 2 DIABETES
- Chronic exposure to parabens promotes non-alcoholic fatty liver disease in association with the changes of the gut microbiota and lipid metabolism
- A functional genomic framework to elucidate novel causal non-alcoholic fatty liver disease genes
Evidence Blueprint
Sex, Nutrition, and NAFLD: Relevance of Environmental Pollution
☊ AI-Driven Related Evidence Nodes
(recent articles with at least 5 words in title)
More Evidence
Sex, Nutrition, and NAFLD: Relevance of Environmental Pollution
🌐 365 Days
VR Related Evidence Matrix
- Non-Alcoholic Fatty Liver Disease and Bone Tissue Metabolism: Current Findings and Future Perspectives
- Enhanced non-alcoholic fatty liver detection: Computed tomography scan image analysis and noise reduction with morphological dilation
- Effect of the nomenclature of non-alcoholic fatty liver disease on diagnosis and treatment of fatty liver disease concomitant with other liver diseases
- Association of 24 h Behavior Rhythm with Non-Alcoholic Fatty Liver Disease among American Adults with Overweight/Obesity
- Challenges and Solutions in the Management of Hepatocellular Carcinoma Associated with Non-Alcoholic Fatty Liver Disease
- New Insights into Nutrition and Gut-Liver Axis: A Focus on Non-Alcoholic Fatty Liver Disease
- SGLT-2 Inhibitors for Non-Alcoholic Fatty Liver Disease: A Review
- Muscle strength and non-alcoholic fatty liver disease/metabolic-associated fatty liver disease
- Exploring the role of genetic variations in NAFLD: implications for disease pathogenesis and precision medicine approaches
- Non-alcoholic fatty liver disease: pathophysiological concepts and treatment options
- The Role of Vitamin D in Obese Children with Non-Alcoholic Fatty Liver Disease and Associated Metabolic Syndrome
- Impact of Porphyromonas gingivalis-odontogenic infection on the pathogenesis of non-alcoholic fatty liver disease
- Anti-Angiogenic Effects of Natural Compounds in Diet-Associated Hepatic Inflammation
- Signs of non-alcoholic fatty liver disease in indigenous Arctic populations - a systematic review
- Type 2 Diabetes Mellitus and Liver Disease: Across the Gut-Liver Axis from Fibrosis to Cancer
- Advances in traditional Chinese medicine treatment of non-alcoholic fatty liver disease via farnesoid X receptor
- Diet and non-alcoholic fatty liver disease, a short narrative review
- NASH drug treatment development: challenges and lessons
- Towards precision medicine in non-alcoholic fatty liver disease
- Type 2 Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease, and Metabolic Repercussions: The Vicious Cycle and Its Interplay with Inflammation
- The significance of omega-3 fatty acids in the treatment of non-alcoholic fatty liver disease
- The Association between Liver Enzymes and Mortality Stratified by Non-Alcoholic Fatty Liver Disease: An Analysis of NHANES III
- Mitochondrial metabolic dysfunction and non-alcoholic fatty liver disease: new insights from pathogenic mechanisms to clinically targeted therapy
- Crohn´s disease is an independent risk factor for liver fibrosis in patients with inflammatory bowel disease and non-alcoholic fatty liver disease
- Genetic and Metabolic Characteristics of Lean Nonalcoholic Fatty Liver Disease in a Korean Health Examinee Cohort
- Akkermansia muciniphila - a Potential Next-generation Probiotic for Non-alcoholic Fatty Liver Disease
- NAFLD Fibrosis Progression and Type 2 Diabetes: The Hepatic-Metabolic Interplay
- The challenging role of micro-RNAs in non-alcoholic fatty liver disease in children with obesity: is it time for a new era?
- Insights into the role of vitamin D in targeting the culprits of non-alcoholic fatty liver disease
- Adlercreutzia equolifaciens Is an Anti-Inflammatory Commensal Bacterium with Decreased Abundance in Gut Microbiota of Patients with Metabolic Liver Disease
- Liver health and the interplay between obesity, alcohol and bariatric surgery
- Integrated traditional Chinese and Western medicine in the prevention and treatment of non-alcoholic fatty liver disease: future directions and strategies
- Glucokinase regulatory protein: a balancing act between glucose and lipid metabolism in NAFLD
- Hepatocellular and extrahepatic cancer risk in people with non-alcoholic fatty liver disease
- MASLD: a systemic metabolic disorder with cardiovascular and malignant complications
- Comprehensive analysis of epigenetic and epitranscriptomic genes' expression in human NAFLD
- Iron metabolism and ferroptosis in Non-alcoholic fatty liver disease: what is our next step?
- Metabolic dysfunction: The silenced connection with fatty liver disease
- Survey of Dietary Habits and Physical Activity in Japanese Patients with Non-Obese Non-Alcoholic Fatty Liver Disease
- Corrected and republished from: Metabolic associated liver disease
- The Presence of Periodontitis Exacerbates Non-Alcoholic Fatty Liver Disease via Sphingolipid Metabolism-Associated Insulin Resistance and Hepatic Inflammation in Mice with Metabolic Syndrome
- Berberine prevents NAFLD and HCC by modulating metabolic disorders
- Non-alcoholic fatty liver disease is associated with hyperandrogenism in women with polycystic ovary syndrome
- Non-alcoholic fatty liver disease and periodontal disease: A systematic review and meta-analysis of cross-sectional studies
- Therapeutic management of metabolic dysfunction associated steatotic liver disease
- Occult liver disease: a multinational perspective
- Association of non-high-density lipoprotein cholesterol trajectories with the development of non-alcoholic fatty liver disease: an epidemiological and genome-wide association study
- Plastic compounds and liver diseases: Whether bisphenol A is the only culprit
- The therapeutic mechanisms and beneficial effects of ursodeoxycholic acid in the treatment of nonalcoholic fatty liver disease: a systematic review
- Lian-Mei-Yin formula alleviates diet-induced hepatic steatosis by suppressing Yap1/FOXM1 pathway-dependent lipid synthesis
- Omega-3 intake is associated with liver disease protection
- Dysregulation of Lipid and Glucose Metabolism in Nonalcoholic Fatty Liver Disease
- Advances in management of metabolic dysfunction-associated steatotic liver disease: from mechanisms to therapeutics
- Prevalence of non-alcoholic fatty liver and its related factors in Iran: Systematic review and meta-analysis
- The Correlation Between Serum Copper and Non-alcoholic Fatty Liver Disease in American Adults: an Analysis Based on NHANES 2011 to 2016
- Management of cardiovascular risk in patients with metabolic dysfunction-associated steatotic liver disease
- Behaviour regulation and the role of mental health in non-alcoholic fatty liver disease
- The relationship between alcohol consumption and chronic kidney disease in patients with nonalcoholic fatty liver disease
- Role of BMI in the relationship between dietary inflammatory index and non-alcoholic fatty liver disease: an intermediary analysis
- Immunology of gut microbiome and liver in non-alcoholic fatty liver disease (NAFLD): mechanisms, bacteria, and novel therapeutic targets
- Non-alcoholic fatty liver disease is associated with an increased risk of type 2 diabetes
- A High-Fat Diet Increases the Characteristics of Gut Microbial Composition and the Intestinal Damage Associated with Non-Alcoholic Fatty Liver Disease
- Association between dietary vitamin A intake from different sources and non-alcoholic fatty liver disease among adults
- How far are we from an approved drug for non-alcoholic steatohepatitis?