AI Summary
- Recognise behavioural traits are highly polygenic and pleiotropic, requiring models beyond single-variant effects to capture genetic complexity and small effect sizes.
- Integrate gene-environment interplay, developmental timing and population diversity to avoid misleading causal inference and improve predictive validity.
- Prioritise ethical governance, diverse sampling and transparent reporting to ensure responsible translation and to mitigate social harms from genetic research.
Nat Genet. 2026 Jul 14. doi: 10.1038/s41588-026-02668-x. Online ahead of print.
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PMID:42449151 | DOI:10.1038/s41588-026-02668-x
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