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When disease illuminates physiology: mapping hidden fluid pathways in the human brain

AI Summary
  • Pathological states expose concealed cerebrospinal and interstitial fluid pathways, enabling physiological mapping otherwise inaccessible in health.
  • Advanced imaging and tracer studies reveal glymphatic and meningeal lymphatic routes, redefining brain clearance and fluid dynamics.
  • Understanding these pathways informs mechanisms of neurodegeneration, diagnostics and targeted therapies for fluid related neurological disorders.
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Brain. 2026 Sep 24:awag315. doi: 10.1093/brain/awag315. Online ahead of print.

NO ABSTRACT

PMID:42779410 | DOI:10.1093/brain/awag315

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