Category: Substance Use Disorders

From Golden Berry To Golden Nanoprobe: Sustainable Fluorescent Sensing of Torsemide For Doping Control in Athletes

J Fluoresc. 2026 Aug 8. doi: 10.1007/s10895-026-04898-y. Online ahead of print.ABSTRACTDoping represents a critical threat to the integrity of competitive sports, with diuretics frequently misused...

RAISR4D Substance Use Disorders

Allosteric switching of Ca2+ permeability in the lysosomal ion channel TPC2 underpins biased agonist activation

EMBO J. 2026 Aug 7. doi: 10.1038/s44318-026-00882-1. Online ahead of print.ABSTRACTIon channels possess selectivity filters that are hardwired to ensure the selective passage of ions....

RAISR4D Substance Use Disorders

Misalignment between ultra-processed status and ‘better for you’ claims on premix alcohol products

Int J Drug Policy. 2026 Jul 6:105395. doi: 10.1016/j.drugpo.2026.105395. Online ahead of print.ABSTRACTBACKGROUND: Premix alcohol products (also known as ready-to-drink beverages) are a rapidly expanding...

RAISR4D Substance Use Disorders

Circadian proteolysis by the E3 ubiquitin ligase gp78 controls CYP3A4 activity in human hepatocytes

Biochem Pharmacol. 2026 Aug 7:118330. doi: 10.1016/j.bcp.2026.118330. Online ahead of print.ABSTRACTThe pharmacokinetics and pharmacodynamics of many drugs vary with the time of administration, reflecting circadian...

RAISR4D Substance Use Disorders

Synaptic reorganization following developmental exposure to substances of abuse: A scoping review of preclinical models

Prog Neuropsychopharmacol Biol Psychiatry. 2026 Aug 7:111884. doi: 10.1016/j.pnpbp.2026.111884. Online ahead of print.ABSTRACTBACKGROUND: The development of the brain involves extensive structuring of neural circuit architecture....

RAISR4D Substance Use Disorders

Adolescent trajectories of psychotic-like experiences and autistic traits and their association with cognition, environmental adversity, and white matter microstructure in the ABCD Study

Biol Psychiatry Cogn Neurosci Neuroimaging. 2026 Aug 7:S2451-9022(26)00230-2. doi: 10.1016/j.bpsc.2026.07.016. Online ahead of print.ABSTRACTBACKGROUND: Psychotic-like experiences (PLEs) and autistic traits across development are associated with...

RAISR4D Substance Use Disorders

Comparison of persons who died of drug overdoses with and without evidence of hepatitis C, United States, 2019-2024

Drug Alcohol Depend. 2026 Aug 1;287:113295. doi: 10.1016/j.drugalcdep.2026.113295. Online ahead of print.ABSTRACTBACKGROUND: Injection drug use is the most common risk factor for hepatitis C virus...

RAISR4D Substance Use Disorders

Microdosing psychedelics: What, why, when, and how often? Insights from an international survey of people who use psychedelics

Int J Drug Policy. 2026 Aug 7;156:105459. doi: 10.1016/j.drugpo.2026.105459. Online ahead of print.ABSTRACTBACKGROUND: The interest in microdosing psychedelics continues to grow within academic and recreational...

RAISR4D Substance Use Disorders

Advances in dopamine transporter inhibitors: Design strategies, structural features, and pharmacological insights

Eur J Med Chem. 2026 Aug 4;318:119189. doi: 10.1016/j.ejmech.2026.119189. Online ahead of print.ABSTRACTDopamine transporter (DAT) plays a pivotal role in regulating synaptic dopamine homeostasis and...

RAISR4D Substance Use Disorders

Vesicular Monoamine Transporters at the Crossroads of Structure and Function: Advances, Challenges, and Future Perspectives

Annu Rev Pharmacol Toxicol. 2026 Aug 7. doi: 10.1146/annurev-pharmtox-060225-123449. Online ahead of print.ABSTRACTMonoaminergic signaling controls many aspects of human physiology, including autonomic responses, movement, and...

RAISR4D Substance Use Disorders

PF5190457 reduces fentanyl intake and seeking with a low risk pharmacological profile in male rats

J Pharmacol Exp Ther. 2026 Jun 26:104978. doi: 10.1016/j.jpet.2026.104978. Online ahead of print.ABSTRACTThe opioid epidemic remains a persistent public health challenge in the United States,...

RAISR4D Substance Use Disorders

Heart-on-a-Chip: Theory, Evidence, and Personalised Medicine

Heart Lung Circ. 2026 Aug 6:S1443-9506(26)00211-8. doi: 10.1016/j.hlc.2026.03.060. Online ahead of print.ABSTRACTCardiovascular research traditionally relies on animal models or isolated cell cultures, each having limitations...

RAISR4D Substance Use Disorders

Brain Network Signatures of Heightened Attention From Methamphetamine

Biol Psychiatry Cogn Neurosci Neuroimaging. 2026 Aug;11(8):897-898. doi: 10.1016/j.bpsc.2026.06.009.NO ABSTRACTPMID:42562568 | DOI:10.1016/j.bpsc.2026.06.009

RAISR4D Substance Use Disorders

Meeting the Needs of Neurodivergent Teens for Dialectical Behaviour Therapy: Challenges and Adaptation Strategies From Clinicians, Teens With Fetal Alcohol Spectrum Disorders and Caregivers

J Appl Res Intellect Disabil. 2026 Jul;39(4):e70290. doi: 10.1111/jar.70290.ABSTRACTPURPOSE: Neurodivergent teens experience elevated emotion dysregulation yet are excluded from treatment trials designed to address these...

RAISR4D Substance Use Disorders

Convergent pathology, divergent pathways: Structural network dissociation of trait and cognitive disinhibition in cocaine use disorder

Prog Neuropsychopharmacol Biol Psychiatry. 2026 Aug 6:111883. doi: 10.1016/j.pnpbp.2026.111883. Online ahead of print.ABSTRACTThe transdiagnostic dimensional framework implicates disinhibition as a core dimension associated with cocaine...

RAISR4D Substance Use Disorders

Correspondence: “Breaking the chains of depression: A systematic review and meta-analysis of psilocybin therapy”

J Affect Disord. 2026 Aug 6:122315. doi: 10.1016/j.jad.2026.122315. Online ahead of print.NO ABSTRACTPMID:42562064 | DOI:10.1016/j.jad.2026.122315

RAISR4D Substance Use Disorders

Postoperative Intravenous Ketorolac Does Not Affect Nonunion Risk in Surgically Treated Long Bone Shaft Fractures

J Am Acad Orthop Surg Glob Res Rev. 2026 Aug 4;10(8). doi: 10.5435/JAAOSGlobal-D-25-00329. eCollection 2026 Aug 1.ABSTRACTBACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) have become an increasingly...

RAISR4D Substance Use Disorders

Multilevel drivers and constraints of shifts from injecting to smoking opioids and stimulants: A qualitative study from the San Diego-Tijuana border region

Drug Alcohol Depend. 2026 Jul 28;287:113279. doi: 10.1016/j.drugalcdep.2026.113279. Online ahead of print.ABSTRACTBACKGROUND: Amidst declines in injecting opioids and stimulants across North America, we sought to...

RAISR4D Substance Use Disorders

Exploring molecular signatures of exposure to water disinfection by-products: A multi-omic analysis across multiple exposure routes

Environ Int. 2026 Jul 28;215:110442. doi: 10.1016/j.envint.2026.110442. Online ahead of print.ABSTRACTBACKGROUND: Disinfection by-products, including those arising from secondary reactions between chlorinated reagents and natural organic...

RAISR4D Substance Use Disorders

Effectiveness of Embedded Social Media Content on E-cigarette Attitudes and Behaviors: Results from a Randomized Control Trial

Addict Behav. 2026 Aug 1;183:108824. doi: 10.1016/j.addbeh.2026.108824. Online ahead of print.ABSTRACTBACKGROUND: This longitudinal randomized controlled trial examined the effects of anti-vaping social media content on...

RAISR4D Substance Use Disorders

06/08/2026

Targeting a novel metabolic vulnerability of non-small cell lung cancer to fatty acid oxidation surmounts chemoresistance

Drug Resist Updat. 2026 Aug 2;89:101462. doi: 10.1016/j.drup.2026.101462. Online ahead of print.ABSTRACTAIMS: Non-small cell lung cancer (NSCLC) patients treated with platinum drugs develop chemoresistance. C/EBPβ...

RAISR4D Substance Use Disorders

Neuroinflammatory pathways linking pain and rehabilitation outcomes in schizophrenia: a narrative review

Pain Manag. 2026 Aug 3:1-19. doi: 10.1080/17581869.2026.2713532. Online ahead of print.ABSTRACTINTRODUCTION: Schizophrenia is a chronic and disabling neuropsychiatric disorder traditionally defined by psychotic and cognitive...

RAISR4D Substance Use Disorders

Cross-sectional associations between neurodiversity and violence-related attendances in Welsh Emergency Departments and the role of Hospital-based Violence Intervention Programmes

Emerg Med J. 2026 Aug 3:emermed-2025-215624. doi: 10.1136/emermed-2025-215624. Online ahead of print.ABSTRACTBACKGROUND: Neurodiversity, including autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD) and learning difficulties,...

RAISR4D Substance Use Disorders

Kratom at a crossroads: Trends, controversies, and the evidence gap

Cleve Clin J Med. 2026 Aug 3;93(8):487-492. doi: 10.3949/ccjm.93a.25088.ABSTRACTAs kratom products become more widely used in the United States, physicians will be more likely to...

RAISR4D Substance Use Disorders

Antidepressant Use and Withdrawal: A Review of Current Evidence and Clinical Recommendations

Psychiatr Clin North Am. 2026 Sep;49(3):423-438. doi: 10.1016/j.psc.2025.10.002. Epub 2025 Nov 13.ABSTRACTLong-term use of antidepressants increased along with viewing depression as a chronic relapsing condition....

RAISR4D Substance Use Disorders

Targeting pain to improve opioid use disorder treatment outcomes: Results of a randomized trial

J Subst Use Addict Treat. 2026 Aug 3:210079. doi: 10.1016/j.josat.2026.210079. Online ahead of print.ABSTRACTINTRODUCTION: Chronic pain is highly prevalent in adults receiving medications for opioid...

RAISR4D Substance Use Disorders

An fMRI-neurofeedback system to train the reward neurocircuitry in ultra-high field MRI: a feasibility study

J Neural Eng. 2026 Aug 3. doi: 10.1088/1741-2552/ae93fa. Online ahead of print.ABSTRACTOBJECTIVE: This feasibility study provides a technical validation of a functional magnetic resonance imaging-based...

RAISR4D Substance Use Disorders

Beyond task sharing: the next step for global mental health

Lancet Psychiatry. 2026 Aug 3:S2215-0366(26)00236-1. doi: 10.1016/S2215-0366(26)00236-1. Online ahead of print.NO ABSTRACTPMID:42546731 | DOI:10.1016/S2215-0366(26)00236-1

RAISR4D Substance Use Disorders

The transactional cycle between neuroticism and Internet gaming disorder in adolescents: Future time perspective as a cognitive mediator in a longitudinal model

Addict Behav. 2026 Jul 29;183:108818. doi: 10.1016/j.addbeh.2026.108818. Online ahead of print.ABSTRACTOBJECTIVE: Based on the Interaction of Person-Affect-Cognition-Execution (I-PACE) model, this study tests a transactional model...

RAISR4D Substance Use Disorders

Understanding the early exposure and potential impact of alcohol health warning labels in Ireland: results from a cross-sectional survey

Int J Drug Policy. 2026 Aug 3;156:105443. doi: 10.1016/j.drugpo.2026.105443. Online ahead of print.ABSTRACTBACKGROUND: In 2025, the new Irish alcohol warning labels started appearing on the...

RAISR4D Substance Use Disorders

Temporal Drivers of Opioid-Related ED Visits: An Ensemble Machine Learning Study With Consensus-Based Feature Attribution

Clin Transl Sci. 2026 Aug;19(8):e70690. doi: 10.1111/cts.70690.ABSTRACTIdentification of modifiable risk factors for prescription opioid use disorder (OUD)-related emergency department (ED) visits (ICD-10 F11.xx) is a...

RAISR4D Substance Use Disorders

Comparison of Johnsons, Inslers formula and ultrasound for estimating fetal weight

Matern Health Neonatol Perinatol. 2026 Aug 3;12(1):31. doi: 10.1186/s40748-026-00280-9.ABSTRACTBACKGROUND: Accurate estimation of fetal weight is a crucial component of pregnancy management and plays a key...

RAISR4D Substance Use Disorders

Promoting smoking cessation and preventing relapse to tobacco use following a smokefree mental health in-patient stay: A multi-centre randomised controlled feasibility study

Addiction. 2026 Aug 2. doi: 10.1111/add.70519. Online ahead of print.ABSTRACTAIMS: This study assessed the feasibility and acceptability of a new theory- and evidence-based intervention designed...

RAISR4D Substance Use Disorders

Longitudinal investigation on the bidirectional association between negative emotions and mobile phone addiction among adolescents in Xinxiang City, 2022-2023

Wei Sheng Yan Jiu. 2026 Jul;55(4):647-684. doi: 10.19813/j.cnki.weishengyanjiu.2026.04.018.ABSTRACTOBJECTIVE: To investigate the prevalence of negative emotions and mobile phone addiction among adolescents and explore the longitudinal...

RAISR4D Substance Use Disorders

Cannabis use disorder in patients prescribed medical cannabis-Should we consider prescription cannabis use disorder as a new diagnostic condition?

Addiction. 2026 Aug 2. doi: 10.1111/add.70559. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: The introduction of prescribed medical cannabis in many parts of the world raises...

RAISR4D Substance Use Disorders

Corrigendum to “Validation of the SPF-10: A new scale for assessing self-perceived functioning in schizophrenia. The VALFASS study” [J. Psychiatr. Res. 201 (2026) 526-538]

J Psychiatr Res. 2026 Aug 1;201:714. doi: 10.1016/j.jpsychires.2026.07.026. Online ahead of print.NO ABSTRACTPMID:42542091 | DOI:10.1016/j.jpsychires.2026.07.026

RAISR4D Substance Use Disorders

gp91phox regulates Hv1 channel gating and membrane trafficking via direct interaction

Biochem Biophys Res Commun. 2026 Jul 30;832:154377. doi: 10.1016/j.bbrc.2026.154377. Online ahead of print.ABSTRACTVoltage-gated proton channel (Hv1) and the NADPH oxidase (NOX2) functionally cooperate to support...

RAISR4D Substance Use Disorders

Cannabis, Cocaine and Crack Before or During Sex and Inconsistent Condom Use with Casual Partners Among Transgender Women in Brazil: A Cross-Sectional Study

Subst Use Misuse. 2026 Aug 1:1-7. doi: 10.1080/10826084.2026.2709655. Online ahead of print.ABSTRACTBackground: Transgender women and travestis (TWT) in Brazil have a disproportionately high prevalence of...

RAISR4D Substance Use Disorders

Beyond Event Counting: A Nurse Practitioner-Led Transparency and Repair Framework for Reducing Coercion in Acute Child and Adolescent Psychiatry

J Child Adolesc Psychiatr Nurs. 2026 Aug;39(3):e70070. doi: 10.1111/jcap.70070.NO ABSTRACTPMID:42541356 | DOI:10.1111/jcap.70070

RAISR4D Substance Use Disorders

Trauma-informed care within oncology? Understanding the impact of childhood trauma on experiences of cancer and cancer services in adulthood

Br J Health Psychol. 2026 Sep;31(3):e70098. doi: 10.1111/bjhp.70098.ABSTRACTOBJECTIVES: This research aimed to explore whether Adverse Childhood Experiences (ACEs) shape adults' engagement with cancer services, including...

RAISR4D Substance Use Disorders

Expanding the boundaries of harm reduction: Why anabolic-androgenic steroid users require a paradigm shift

Addiction. 2026 Jul 30. doi: 10.1111/add.70564. Online ahead of print.NO ABSTRACTPMID:42533255 | DOI:10.1111/add.70564

RAISR4D Substance Use Disorders

Neurostructural Correlates and Impulsive Mechanisms of Exercise Dependence in Middle-Aged and Elderly Adults: Evidence from Gray Matter and Structural Covariance Networks

Brain Topogr. 2026 Jul 30;39(5):86. doi: 10.1007/s10548-026-01241-3.ABSTRACTExercise dependence is characterized by excessive, uncontrollable exercise behavior accompanied by physiological or psychological symptoms. While its existence has...

RAISR4D Substance Use Disorders

A cortical insula-orbitofrontal circuit drives stress-induced dopamine system dysfunction

Mol Psychiatry. 2026 Jul 30. doi: 10.1038/s41380-026-03791-1. Online ahead of print.ABSTRACTStress is a major risk factor for psychiatric disorders, including post-traumatic stress disorder (PTSD), depression,...

RAISR4D Substance Use Disorders

Peripartum Management for Patients Receiving Medication for Opioid Use Disorder

Anesthesiol Clin. 2026 Sep;44(3):395-410. doi: 10.1016/j.anclin.2026.04.001. Epub 2026 Jun 5.ABSTRACTThis review discusses the rising impact of opioid use disorder (OUD) on peripartum care, highlighting the...

RAISR4D Substance Use Disorders