AI Summary
- Pilot data suggest single IV ketamine was generally safe and tolerable in older adults with depression and mild cognitive impairment, with mostly transient adverse effects.
- No clear cognitive decline detected short term, but small sample and brief follow up limit conclusions about longer term cognitive safety.
- Authors recommend larger randomised trials with extended monitoring for efficacy, cognitive outcomes and cardiovascular or neuropsychiatric adverse events.
Am J Geriatr Psychiatry. 2026 Jul 30:S1064-7481(26)00480-X. doi: 10.1016/j.jagp.2026.07.013. Online ahead of print.
NO ABSTRACT
PMID:42629230 | DOI:10.1016/j.jagp.2026.07.013
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