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Default-Mode Network Functional Connectivity: A Potential Therapeutic Target in Posttraumatic Stress Disorder

AI Summary
  • Altered default mode network functional connectivity (DMN-FC) is implicated in PTSD pathophysiology, affecting self-referential processing and memory.
  • Modulation of DMN functional connectivity offers a promising therapeutic target, accessible via pharmacological, psychotherapeutic and neuromodulatory interventions.
  • DMN functional connectivity may act as a biomarker to predict treatment response and personalise interventions in PTSD clinical trials.
Summarise with AI (MRCPsych/FRANZCP)

Brain Connect. 2026 Aug 17:21580014261479966. doi: 10.1177/21580014261479966. Online ahead of print.

NO ABSTRACT

PMID:42608962 | DOI:10.1177/21580014261479966

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