AI Summary
- Compulsivity in eating disorders and obsessive-compulsive disorder reflects shared molecular pathogenic processes.
- Breen et al. analysed postmortem human fronto-striatal tissue to profile transcriptomic alterations across ED and OCD.
- Systems-level molecular convergence centred on neuronal energetics and synaptic signalling, indicating common pathogenic targets.
Trends Neurosci. 2026 Aug 11:S0166-2236(26)00139-6. doi: 10.1016/j.tins.2026.07.001. Online ahead of print.
ABSTRACT
The shared features of compulsivity in eating disorders (EDs) and obsessive-compulsive disorder (OCD) may reflect common molecular pathogenic processes. In a recent study, Breen et al. used postmortem human brain tissue to investigate fronto-striatal transcriptomic alterations in ED and OCD, identifying systems-level molecular convergence centered on neuronal energetics and synaptic signaling.
PMID:42580972 | DOI:10.1016/j.tins.2026.07.001
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