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LLMs as Clinical Instruments-Toward Verifiable Reasoning

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LLMs offer diagnostic and therapeutic support but must provide verifiable reasoning to be trusted in clinical decision making.
Require rigorous validation, transparency, and audit trails to ensure reliability, reproducibility, and alignment with evidence-based psychiatric standards.
Clinical deployment needs human oversight, continual monitoring, risk mitigation, and regulatory frameworks to protect patient safety and reduce bias.

JAMA Psychiatry. 2026 Jul 29. doi: 10.1001/jamapsychiatry.2026.2211. Online ahead of print.

NO ABSTRACT

PMID:42525421 | DOI:10.1001/jamapsychiatry.2026.2211

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