AI Summary
- First-line pharmacotherapies: oral or extended release naltrexone and acamprosate reduce heavy drinking and help maintain abstinence; choose by patient profile.
- Disulfiram, topiramate, and gabapentin are alternatives with variable evidence and specific monitoring needs; consider comorbidities and adherence.
- Medications remain underused; integrate pharmacotherapy with psychosocial support and offer treatment in primary care to improve access and outcomes.
JAMA. 2026 Aug 19. doi: 10.1001/jama.2026.10575. Online ahead of print.
NO ABSTRACT
PMID:42616548 | DOI:10.1001/jama.2026.10575
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