- Pooled dementia prevalence in older adults with psychotic disorders was 24.3% (95% CI 20.5% to 28.5%) after excluding one outlier.
- Estimates were highly heterogeneous; key contributors included prevalence type, setting, geographical region and age, with dementia incidence varying widely.
- Findings highlight elevated but heterogeneous dementia rates and call for more population-based studies to guide integrated service planning.
Asia Pac Psychiatry. 2026 Sep;18(3):e70033. doi: 10.1111/appy.70033.
ABSTRACT
People with psychotic disorders have higher dementia risk. This study aimed to investigate the prevalence and incidence of dementia in this population. Data were synthesized through meta-analysis (including subgroup and sensitivity analyses) and narrative synthesis. The pooled dementia prevalence was 24.3% (95% CI: 20.5%-28.5%, I2 = 84.7%, p < 0.001) in older adults after excluding one outlier. Factors contributing to heterogeneity included prevalence types, settings, geographical regions, and age. The dementia incidence varied widely. This review identified elevated but heterogeneous dementia rates in psychotic disorders, calling for more population-based studies to provide evidence for integrated service planning.
PMID:42615098 | DOI:10.1111/appy.70033
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