- Primary cerebral sarcoma in right temporal lobe of a 59-year-old man with prior pituitary tumour resection and postoperative radiotherapy about 40 years earlier.
- Tumour showed loose, diffuse proliferation of large pleomorphic cells in markedly myxoid stroma with delicate collagen and pseudolipoblasts.
- Many eosinophilic hyaline globules were present; tumour lost nuclear H3K27me3 expression yet lacked detectable DICER1 mutations despite resemblance to myxofibrosarcoma.
Neuropathology. 2026 Oct;46(5):e70077. doi: 10.1111/neup.70077.
ABSTRACT
A case of primary sarcoma that arose in the right temporal lobe of a 59-year-old man is reported. The patient had a history of resection of a “pituitary tumor” and postoperative radiotherapy about 40 years earlier. The cerebral tumor consisted of loose and diffuse proliferation of large pleomorphic cells in a matrix showing a markedly myxoid change and containing a variable amount of delicate collagen fibers. Some tumor cells had a large intracytoplasmic vacuole containing acid mucopolysaccharide, thus featuring “pseudolipoblasts.” Differentiation along other specific mesenchymal lineages was not found. Many tumor cells contained densely eosinophilic hyaline globules in the cytoplasm. Tumor cells showed a loss of the nuclear expression of H3K27me3. Although cerebral sarcomas showing similar histopathological features have not been previously reported, a markedly myxoid change of the stroma admixed with delicate collagen fibers and “pseudolipoblasts” suggests a close pathological kinship to myxofibrosarcoma. Another notable finding was the appearance of many hyaline globules, which has been considered a characteristic finding of primary intracranial sarcoma, DICER1-mutant. In the cytogenetic study of the present case, however, no DICER1 gene mutations were demonstrated.
PMID:42702563 | DOI:10.1111/neup.70077
Share Evidence Blueprint
Save to Google Notes
Search Google Scholar
Save as PDF
⭐ My Revision List
