- Primary chest wall malignant lymphoma is rare and typically associated with chronic pyothorax, tuberculosis, artificial pneumothorax, or EBV infection.
- Case: 65-year-old woman with left rib fractures had a 30 mm × 10 mm enlarging chest wall mass beneath the seventh rib, without rib invasion.
- Thoracoscopic and open resection performed; histology revealed diffuse large B-cell lymphoma, showing chest wall lymphoma can arise absent known underlying disease.
Cureus. 2026 Aug 5;18(8):e114033. doi: 10.7759/cureus.114033. eCollection 2026 Aug.
ABSTRACT
Primary malignant lymphoma of the chest wall is a rare disease. Its pathogenesis has been reported to be associated with chronic pyothorax following tuberculous inflammation, artificial pneumothorax, and Epstein-Barr virus (EBV) infection. We herein report a surgically treated case of primary chest wall lymphoma without a history of tuberculosis or chronic pyothorax. A 65-year-old woman with a history of left rib fractures caused by domestic violence was found to have an abnormal shadow in the left chest on a chest radiograph obtained during a routine medical checkup. Contrast-enhanced computed tomography (CECT) revealed a mass lesion in the left chest wall, and she was referred to our department for further evaluation and treatment. Examination demonstrated a gradually enlarging mass measuring 30 mm × 10 mm located just below the left seventh rib. No obvious invasion into the ribs or surrounding organs and tissues was observed. Tumor resection was performed under thoracoscopic and direct visualization. Histopathological examination revealed diffuse large B-cell lymphoma (DLBCL). We experienced a surgically treated case of primary chest wall malignant lymphoma without any apparent underlying disease that could have contributed to its development.
PMID:42701364 | PMC:PMC13545020 | DOI:10.7759/cureus.114033
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