AI Summary
- Tirzepatide initiation precipitated lithium toxicity by promoting dehydration and reduced renal clearance, causing elevated lithium levels and neurological features.
- After starting tirzepatide, clinicians must monitor lithium concentrations and renal function and advise patients about volume loss and gastrointestinal effects.
- Treatment includes supportive care, withholding or reducing lithium, aggressive fluid resuscitation, and dialysis for severe or life threatening toxicity.
J Clin Psychopharmacol. 2026 Oct 19. doi: 10.1097/JCP.0000000000002271. Online ahead of print.
NO ABSTRACT
PMID:42895194 | DOI:10.1097/JCP.0000000000002271
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