- Topiramate dose-dependently reduced ethanol binge-like intake: 60 mg/kg decreased consumption, and 30 and 60 mg/kg lowered blood ethanol concentrations; males drank more.
- Topiramate did not significantly alter sucrose binge-like intake; females consumed less sucrose than males.
- Topiramate reduced anxiety-like behaviour in the elevated plus maze regardless of sex, and altered marble burying results with sex-dependent effects likely reflecting a floor effect.
Psychopharmacology (Berl). 2026 Sep 14. doi: 10.1007/s00213-026-07166-w. Online ahead of print.
ABSTRACT
RATIONALE: Repetitive binge episodes are early-stage patterns in the addiction cycle associated with elevated anxiety and compulsive traits. Despite their high comorbidity and the growing off-label use of topiramate for binge-related disorders, its effects in non-dependent individuals remain poorly characterized and studies systematically comparing both sexes under identical experimental conditions remain scarce.
OBJECTIVES: To evaluate the effects of topiramate on ethanol (EtOH) and sucrose binge-like intake, anxiety- and compulsive-like responses in non-dependent male and female C57BL/6J mice.
METHODS: EtOH (20% v/v) and sucrose (10% w/v) binge-like intake were assessed in a standard Drinking in the Dark (DID) procedure following intraperitoneal topiramate (0, 30, or 60 mg/kg). Blood EtOH concentrations (BECs) were determined after EtOH DID. Anxiety-like and compulsive-like behaviors were assessed using the Elevated Plus Maze (EPM) and Marble Burying (MB) test.
RESULTS: Topiramate significantly reduced EtOH binge-like intake at 60 mg/kg and BECs at 30 and 60 mg/kg, while males consumed more EtOH and showed higher BECs than females. Topiramate did not significantly alter sucrose binge-like intake, with females consuming less sucrose than males. Topiramate significantly reduced anxiety-like behavior in the EPM regardless of sex. In the MB test, the topiramate effect differed significantly across sexes, although these results most likely reflect a floor effect in vehicle-treated females.
CONCLUSIONS: These findings provide preliminary evidence that topiramate reduces EtOH binge-like intake, anxiety- and compulsive-like behavior in non-dependent mice with a non-significant attenuation of sucrose binge-like intake. Further research is warranted to establish the translational relevance and to evaluate the preventive potential of topiramate in binge-related disorders.
PMID:42733100 | DOI:10.1007/s00213-026-07166-w
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