Proc Natl Acad Sci U S A. 2026 May 5;123(18):e2533728123. doi: 10.1073/pnas.2533728123. Epub 2026 Apr 30.
ABSTRACT
Ketamine has been shown to reduce depression and suicidality in individuals resistant to treatment by other drugs. Exactly how ketamine works is not known. Here, I propose a new hypothesis that involves synaptic and circuit plasticity and may lead to enhanced efficacy in treating depression as well as other conditions.
PMID:42060723 | DOI:10.1073/pnas.2533728123
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